(2x+1)(2x-1)(4x^2+1)(x^4+1/16) =(4x^2-1)(4x^2+1)(x^4+1/16) =(16x^4-1)(x^4+1/16) =(16x^4-1)*(1/16)*(16x^4+1) =(1/16)*(16x^4-1)*(16x^4+1) =(1/16)*(256x^8-1) =16x^8-1/16