学习生物的英语达人帮帮忙翻译下这一小段呗,我读了很多遍了,大致的意思是懂了,就是还是很模糊。
还是不能彻底领悟其中的意思,望指导!麻烦您帮忙一下。不胜感激。Asymmetric segregation of polarized antigen on B cell division shapes presentation capacity .During the activation of humoral immune responses ,B cells acquire antigen for subsequent presentation to cognate T cells .Here we show that after mouse B cells accumulate antigen , it is maintained in a polarized distribution for extended periods in vivo. Using high—throughput imaging flow cytometry, we observed that this polarization is preserved during B cell division , promoting asymmetric antigen segregation among progeny . Antigen inheritance correlates with the ability of progency to activate T cells :Daughter cells receiving larger antigen stores exhibit a prolonged capacity to present antigen which renders them more effective in competing for T cell help. The generation of progeny with differential capacities for antigen presentation may have implications for somatic hypermutation and class switching during affinity maturation and as B cells commit to effector cell fates.谢谢大家了。