根据动词的形式不同会产生不同的变化
He is a student. ——He is not a student(is not可缩写为isn't)
He like music.——he doesn't like music(谓语动词是实意动词,要变成主语+don't/doesn't+动词原形+其他)
He can swim——he can't swim(有情态动词,情态动词+not)