把x+y=5两边平方得:(x+y) 2 =25,即x 2 +y 2 +2xy=25, 把xy=4代入得:x 2 +y 2 +8=25,即x 2 +y 2 =17, ∴(x-y) 2 =x 2 +y 2 -2xy=17-8=9, 则x-y=±3, 故答案为:±3