设AC与BD的垂足为O,
∴S △ABC = 1 2 ?AC?OC,S △ADC = 1 2 ?AC?OD,
∴S 四边形ABCD =S △ABC +S △ADC = 1 2 ?AC?OC+ 1 2 ?AC?OD= 1 2 ?AC?BD,
而AC=4,BD=6,
∴S 四边形ABCD = 1 2 ?4?6=12.
故答案为12.