∵菱形ABCD的对角线AC、BD交于点O,AC=16,BD=12,∴AC⊥BD,OC= 1 2 AC=8,OB= 1 2 BD=6,∴BC= OB2+OC2 =10,∵S菱形ABCD=BC?DE= 1 2 AC?BD= 1 2 ×16×12=96,∴DE=9.6.故答案为:9.6.